(19)

(11)

EP 0 518 939 A1

(12)

(43) Date of publication: 23.12.1992 Bulletin 1992/52 (21) Application number: 91905586.0 (22) Date of filing: 11.03.1991

(51) International Patent Classification (IPC):  A61K 31/ 18( . ) A61K 31/ 40( . ) A61K 31/ 404( . ) A61K 31/ 451( . ) A61K 31/ 472( . ) C07C 217/ 36( . ) C07D 209/ 12( . ) C07D 211/ 18( . ) C07D 211/ 22( . ) C07D 217/ 04( . ) C07D 295/ 092( . ) A61K 31/ 19( . ) A61K 31/ 403( . ) A61K 31/ 445( . ) A61K 31/ 47( . ) A61P 9/ 06( . ) C07C 311/ 08( . ) C07D 211/ 14( . ) C07D 211/ 20( . ) C07D 215/ 06( . ) C07D 295/ 08( . ) (86) International application number: PCT/GB1991/000379 (87) International publication number: WO 1991/013865 (19.09.1991 Gazette 1991/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 09.03.1990 GB 19900005318 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventors: GILL, Edward, William Oxford OX2 7TN (GB) TERRAR, Derek Anthony Bladon, Oxford OX7 1XP (GB) CONNORS, Sean, Patrick Saint Johns, New Foundland A1A 1T4 (CA) DENNIS, Paul, David Oxford 0X1 2HG (GB) (74) Representative: Pennant, Pyers  Stevens, Hewlett & Perkins 1 Serjeants' Inn Fleet Street London EC4Y 1LL London EC4Y 1LL (GB)