(19)

(11)

EP 0 519 008 A1

(12)

(43) Date of publication: 23.12.1992 Bulletin 1992/52 (21) Application number: 91906820.0 (22) Date of filing: 08.03.1991

(51) International Patent Classification (IPC):  C07K 14/ 715( . ) C12P 21/ 08( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/001612 (87) International publication number: WO 1991/013984 (19.09.1991 Gazette 1991/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 09.03.1990 US 19900491004 31.08.1990 US 19900575727 (71) Applicant: IMMUNEX CORPORATION Seattle, WA 98101 (US)	(72) Inventors: FANSLOW, William, C. Federal Way, WA 98023 (US) ARMITAGE, Richard, J. Seattle, WA 98103 (US) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)