(19)

(11)

EP 0 522 007 A1

(12)

(43) Date of publication: 13.01.1993 Bulletin 1993/02 (21) Application number: 91907128.0 (22) Date of filing: 14.03.1991

(51) International Patent Classification (IPC):  A61K 49/ 06( . ) A61K 51/ 04( . ) C07D 257/ 00( . ) G01N 33/ 60( . ) A61K 49/ 08( . ) A61K 51/ 10( . ) G01N 33/ 533( . ) (86) International application number: PCT/US1991/001637 (87) International publication number: WO 1991/014458 (03.10.1991 Gazette 1991/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 26.03.1990 US 19900498320 (71) Applicant: THE UNITED STATES OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20231 (US)	(72) Inventors: BRECHBIEL, Martin, W. Annadale, VA 22003 (US) GANSOW, Otto A. Washington, DC 20008 (US) (74) Representative: Davies, Jonathan Mark  Reddie & Grose 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)