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(11)

EP 0 522 176 A1

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(43) Date of publication: 13.01.1993 Bulletin 1993/02 (21) Application number: 92903719.0 (22) Date of filing: 28.01.1992

(51) International Patent Classification (IPC):  A61K 31/ 455( . ) A61P 9/ 10( . ) C07D 211/ 90( . ) A61P 9/ 08( . ) A61P 9/ 12( . ) (86) International application number: PCT/JP1992/000076 (87) International publication number: WO 1992/013839 (20.08.1992 Gazette 1992/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 30.01.1991 GB 19910002031 (71) Applicants: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP) DAICEL CHEMICAL INDUSTRIES, LTD. Sakai-shi Osaka-fu 590 (JP)

(72) Inventors: ITO, Kiyotaka Akashi-shi, Hyogo 674 (JP) AKAMATSU, Hidekazu Tsuchiura-shi, Ibaraki 300 (JP) INOUE, Keizo Tsuchiura-shi, Ibaraki 300 (JP) ONOMURA, Osamu Tsukuba-shi, Ibaraki 305 (JP) HAMATANI, Takeshi Tsukuba-shi, Ibaraki 305 (JP) UEDA, Yoichiro Tsuchiura-shi, Ibaraki 300 (JP) ESUMI, Kimio Kobe-shi, Hyogo 658 (JP) (74) Representative: DELETED Patentanwälte A. Grünecker, H. Kinkeldey W. Stockmair, K. Schumann, P.H. Jakob, G. Bezold R. 101(9) 29.11.1995  Maximilianstrasse 58 D-80538 München D-80538 München (DE)