(19)

(11)

EP 0 523 171 A1

(12)

(43) Date of publication: 20.01.1993 Bulletin 1993/03 (21) Application number: 91908063.0 (22) Date of filing: 03.04.1991

(51) International Patent Classification (IPC):  C12M 1/ 00( . ) C12Q 1/ 68( . ) G01N 33/ 53( . ) G01N 35/ 00( . ) B01L 7/ 00( . ) C12Q 1/ 70( . ) G01N 33/ 543( . ) G01N 35/ 10( . ) (86) International application number: PCT/US1991/002323 (87) International publication number: WO 1991/015768 (17.10.1991 Gazette 1991/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 06.04.1990 US 19900505904 (71) Applicant: SYNGENE, INC. San Diego, CA 92121-2789 (US)	(72) Inventors: JABLONSKI, Edward, G. Escondido, CA 92025 (US) LOHRMANN, Rolf La Jolla, CA 92037 (US) RUTH, Jerry, L. San Diego, CA 92131 (US) TU, Eugene San Diego, CA 92104-4030 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 D-22607 Hamburg D-22607 Hamburg (DE)