STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE - Patent 0525109

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(11)

EP 0 525 109 A1

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(43)	Date of publication:
	03.02.1993 Bulletin 1993/05

(21)	Application number: 91909002.0

(22)	Date of filing: 16.04.1991

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International Patent Classification (IPC):

A61K 31/ 40^{( . )}
A61K 31/ 404^{( . )}
A61K 31/ 4402^{( . )}
A61K 31/ 4409^{( . )}
A61P 9/ 10^{( . )}
C07D 209/ 08^{( . )}
C07D 209/ 18^{( . )}
C07D 213/ 57^{( . )}

A61K 31/ 403^{( . )}
A61K 31/ 44^{( . )}
A61K 31/ 4406^{( . )}
A61K 31/ 4418^{( . )}
A61P 43/ 00^{( . )}
C07D 209/ 12^{( . )}
C07D 213/ 54^{( . )}
C07D 213/ 89^{( . )}

(86)	International application number:
	PCT/US1991/002603

(87)	International publication number:
	WO 1991/016051 (31.10.1991 Gazette 1991/25)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

16.04.1990 US 19900509942

(71)	Applicant: RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
	Lewes, Delaware 19958 (US)

(72)	Inventors:
	SPADA, Alfred, P. Ambler, PA 19002 (US) PERSONS, Paul, E. King of Prussia, PA 19406 (US) LEVITZKI, Alexander 91 999 Jerusalem (IL) GILON, Chaim 91 999 Jerusalem (IL) GAZIT, Aviv 91 999 Jerusalem (IL)

(74)	Representative: Le Pennec, Magali
	RHONE-POULENC SANTE Service Brevets Santé, 20 Avenue Raymond Aron F-92160 Antony F-92160 Antony (FR)

(54)	STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE