(19)

(11)

EP 0 527 767 A1

(12)

(43) Date of publication: 24.02.1993 Bulletin 1993/08 (21) Application number: 91907566.0 (22) Date of filing: 05.04.1991

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61P 31/ 12( . ) C07K 14/ 08( . ) C07K 14/ 195( . ) C07K 14/ 825( . ) C12N 1/ 19( . ) C12N 9/ 10( . ) C12N 15/ 40( . ) C12N 15/ 83( . ) C12R 1/ 19( . ) A61K 39/ 12( . ) C07K 14/ 005( . ) C07K 14/ 16( . ) C07K 14/ 705( . ) C07K 19/ 00( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12N 15/ 81( . ) C12P 21/ 02( . ) C12R 1/ 865( . ) (86) International application number: PCT/AU1991/000128 (87) International publication number: WO 1991/015587 (17.10.1991 Gazette 1991/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 06.04.1990 AU 19900009508 (71) Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Campbell, Australian Capital Territory 2601 (AU)	(72) Inventors: JAGADISH, Mittur, Nanjappa Gladstone Park, VIC 3043 (AU) WARD, Colin, Wesley Balwyn, VIC 3103 (AU) SHUKLA, Dharma, Deo Sunshine, VIC 3020 (AU) (74) Representative: Marshall, Monica Anne  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)