(19)

(11)

EP 0 527 810 A1

(12)

(43) Date of publication: 24.02.1993 Bulletin 1993/08 (21) Application number: 91908404.0 (22) Date of filing: 12.04.1991

(51) International Patent Classification (IPC):  A61K 9/ 50( . ) A61K 35/ 74( . ) (86) International application number: PCT/US1991/002533 (87) International publication number: WO 1991/016064 (31.10.1991 Gazette 1991/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 13.04.1990 US 19900509319 27.04.1990 US 19900515552 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventors: TOMASZ, Alexander New York, NY 10021 (US) TUOMANEN, Elaine New York, NY 10021 (US) (74) Representative: Weinhold, Peter, Dr., et al  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)