(19)

(11)

EP 0 527 914 A1

(12)

(43) Date of publication: 24.02.1993 Bulletin 1993/08 (21) Application number: 91909888.0 (22) Date of filing: 30.04.1991

(51) International Patent Classification (IPC):  A61K 38/ 04( . ) C07K 14/ 575( . ) A61K 38/ 00( . ) A61P 5/ 00( . ) C07K 14/ 60( . ) (86) International application number: PCT/US1991/003053 (87) International publication number: WO 1991/016923 (14.11.1991 Gazette 1991/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 04.05.1990 US 19900519054 (71) Applicant: THE ADMINISTRATORS OF THE TULANE UNIVERSITY EDUCATIONAL FUND New Orleans, LA 70118 (US)	(72) Inventors: COY, David, H. New Orleans, LA 70115 (US) MURPHY, William Covington, LA 70433 (US) HOCART, Simon, J. New Orleans, LA 70122 (US) (74) Representative: Roberts, Alison Christine, et al  Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)