(19)
(11) EP 0 528 686 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.01.2004 Bulletin 2004/03

(45) Mention of the grant of the patent:
05.11.2003 Bulletin 2003/45

(21) Application number: 92307577.4

(22) Date of filing: 19.08.1992
(51) International Patent Classification (IPC)7: C12N 15/62, C12P 21/02, C12N 15/16

(54)

Process for producing peptides

Verfahren zur Herstellung von Peptiden

Procédé pour la production de peptides

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 19.08.1991 JP 23076991
31.07.1992 JP 22352092

(43) Date of publication of application:
24.02.1993 Bulletin 1993/08

(73) Proprietor: Daiichi Suntory Pharma Co., Ltd.
Tokyo (JP)

(72) Inventors:
  • Yabuta, Masayuki
    Tatebayashi-shi, Gunma (JP)
  • Suzuki, Yuji
    Ashikaga-shi, Tochigi (JP)
  • Ohsuye, Kazuhiro
    Ohra-gun, Gunma (JP)
  • Oshima, Takehiro
    Ashikaga-shi, Tochigi (JP)
  • Onai, Seiko
    Isesaki-shi, Gunma (JP)
  • Magota, Koji
    Takatsuki-shi, Osaka (JP)
  • Tanaka, Shoji
    Ashiya-shi, Hyogo (JP)

(74) Representative: Stoner, Gerard Patrick et al
MEWBURN ELLIS York House 23 Kingsway
London WC2B 6HP
London WC2B 6HP (GB)


(56) References cited: : 
EP-A- 0 281 418
   
  • JOURNAL OF BIOCHEMISTRY vol. 102, no. 1 , July 1987 , TOKYO JP pages 111 - 122 SAITO ET AL. 'Bacterial synthesis of recombinant alpha-Human Atrial Natriuretic polypeptide'
  • GENE. vol. 32 , 1984 , AMSTERDAM NL pages 321 - 327 SMITH ET AL. 'Chemical synthesis and cloning of a poly(arginine)-coding gene fragment designated to aid polypeptide purification'
  • LI ET AL.: 'Characterization of mutants affecting the KRK sequence in the C-terminal domain of lac repressor' JOURNAL OF BIOLOGICAL CHEMISTRY vol. 270, no. 18, 05 May 1995, pages 10640 - 10649
  • PARSELL ET AL.: 'The structural stability of a protein is an important determinant of its proteolytic susceptibility in E. coli' JOURNAL OF BIOLOGICAL CHEMISTRY vol. 264, no. 13, 05 May 1989, pages 7590 - 7595
  • TAJIMA ET AL.: 'High-level synthesis in E.coli of recombinant human calcitonin: Collagenase claevage of the fusion protein and peptidylglycine alpha-amidation' JOURNAL OF FERMENTATION AND BIOENGINEERING vol. 72, no. 5, 1991, pages 362 - 367
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).