HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF - Patent 0528951

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EP 0 528 951 A1

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(43)	Date of publication:
	03.03.1993 Bulletin 1993/09

(21)	Application number: 91910051.0

(22)	Date of filing: 29.04.1991

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International Patent Classification (IPC):

A61K 39/ 395^{( . )}
A61P 11/ 00^{( . )}
C07K 16/ 28^{( . )}
C12N 15/ 09^{( . )}
G01N 33/ 53^{( . )}
A61K 38/ 00^{( . )}

A61P 3/ 02^{( . )}
A61P 31/ 12^{( . )}
C12N 5/ 10^{( . )}
C12P 21/ 08^{( . )}
G01N 33/ 531^{( . )}
C12R 1/ 91^{( . )}

(86)	International application number:
	PCT/US1991/002942

(87)	International publication number:
	WO 1991/016927 (14.11.1991 Gazette 1991/26)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

27.04.1990 GB 19900009549

(71)	Applicants:
	CELLTECH LIMITED Slough Berkshire SL1 4EN (GB) Boehringer Ingelheim Pharmaceuticals Inc. Ridgefield Connecticut 06877 (US)

(72)	Inventors:
	ADAIR, John, Robert High Wycombe Buckinghamshire HP14 3RN (GB) ATHWAL, Diljeet, Singh London WC1 (GB) ROTHLEIN, Robert, A. Danbury, CT 06811 (US)

(74)	Representative: Sheard, Andrew Gregory, et al
	Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)

(54)	HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF