(19)

(11)

EP 0 530 207 A1

(12)

(43) Date of publication: 10.03.1993 Bulletin 1993/10 (21) Application number: 91907827.0 (22) Date of filing: 17.04.1991

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) A61P 29/ 00( . ) C07D 471/ 04( . ) A61K 31/ 55( . ) A61P 37/ 08( . ) C07F 7/ 08( . ) (86) International application number: PCT/EP1991/000737 (87) International publication number: WO 1991/017162 (14.11.1991 Gazette 1991/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 09.05.1990 GB 19900010404 (71) Applicants: Pfizer Limited Sandwich Kent CT13 9NJ (GB) PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventors: COOPER, Kelvin Sandwich, Kent CT13 9JN (GB) FRAY, Michael Jonathan Sandwich, Kent CT13 9NJ (GB) STEELE, John Sandwich, Kent CT13 9NJ (GB) (74) Representative: Moore, James William, Dr., et al  Pfizer Limited Ramsgate Road Sandwich Kent CT13 9NJ Sandwich Kent CT13 9NJ (GB)