(19)

(11)

EP 0 530 243 A1

(12)

(43) Date of publication: 10.03.1993 Bulletin 1993/10 (21) Application number: 91909458.0 (22) Date of filing: 22.05.1991

(51) International Patent Classification (IPC):  C07H 21/ 04( . ) C12N 15/ 10( . ) C12Q 1/ 68( . ) C12N 15/ 09( . ) C12N 15/ 12( . ) (86) International application number: PCT/GB1991/000803 (87) International publication number: WO 1991/018114 (28.11.1991 Gazette 1991/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 22.05.1990 GB 19900011454 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: JONES, David, Stephen, Charnock 96 Cambridge Road Cambridge CB2 5JS (GB) ROSENTHAL, Andre Cambridge CB1 40H (GB) (74) Representative: Mercer, Christopher Paul (GB), et al  Carpmaels & Ransford 43 Bloomsbury Square GB-London WC1A 2RA GB-London WC1A 2RA (GB)