(19)

(11)

EP 0 532 584 A1

(12)

(43) Date of publication: 24.03.1993 Bulletin 1993/12 (21) Application number: 91910572.0 (22) Date of filing: 31.05.1991

(51) International Patent Classification (IPC):  C07K 14/ 37( . ) C12Q 1/ 68( . ) (86) International application number: PCT/GB1991/000869 (87) International publication number: WO 1991/019005 (12.12.1991 Gazette 1991/28)

(84) Designated Contracting States: CH DE FR GB LI (30) Priority: 01.06.1990 GB 19900012196 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventors: WAKEFIELD, Ann, Elizabeth Charlbury, Oxford 0X7 3ET (GB) HOPKIN, Julian, Meurglyn Oxford 0X2 6JD (GB) MOXON, Edward, Richard Oxford 0X2 7AX (GB) (74) Representative: Pennant, Pyers, et al  Stevens, Hewlett & Perkins 1 Serjeants' Inn Fleet Street London EC4Y 1LL London EC4Y 1LL (GB)