(19)

(11)

EP 0 532 621 A1

(12)

(43) Date of publication: 24.03.1993 Bulletin 1993/12 (21) Application number: 91911097.0 (22) Date of filing: 05.06.1991

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61P 29/ 00( . ) C07D 213/ 75( . ) A61K 31/ 4418( . ) A61P 43/ 00( . ) C07D 213/ 81( . ) (86) International application number: PCT/US1991/003940 (87) International publication number: WO 1991/018883 (12.12.1991 Gazette 1991/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 07.06.1990 US 19900534387 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406 (US)	(72) Inventors: DAINES, Robert, A. Lansdale, PA 19446 (US) KINGSBURY, William, Dennis Wayne, PA 19087 (US) (74) Representative: Giddings, Peter John, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)