(19)

(11)

EP 0 532 673 A1

(12)

(43) Date of publication: 24.03.1993 Bulletin 1993/12 (21) Application number: 91912258.0 (22) Date of filing: 07.06.1991

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12P 21/ 02( . ) G01N 33/ 53( . ) C07K 14/ 16( . ) C12P 21/ 08( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1991/004021 (87) International publication number: WO 1991/019011 (12.12.1991 Gazette 1991/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 08.06.1990 US 19900535767 (71) Applicant: REPLIGEN CORPORATION Cambridge, MA 02139 (US)	(72) Inventors: RUSCHE, James, R. Framingham, MA 01701 (US) PROFY, Albert, T. Cambridge, MA 02139 (US) (74) Representative: Deans, Michael John Percy (GB), et al  Lloyd Wise, Tregear & Co. Norman House 105-109 Strand GB-London WC2R 0AE GB-London WC2R 0AE (GB)