(19)

(11)

EP 0 532 695 A1

(12)

(43) Date of publication: 24.03.1993 Bulletin 1993/12 (21) Application number: 91913555.0 (22) Date of filing: 30.05.1991

(51) International Patent Classification (IPC):  C07K 7/ 08( . ) C07K 16/ 30( . ) C12N 9/ 24( . ) G01N 33/ 573( . ) C07K 16/ 00( . ) C07K 16/ 40( . ) G01N 33/ 53( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1991/003832 (87) International publication number: WO 1991/019197 (12.12.1991 Gazette 1991/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 31.05.1990 US 19900530869 (71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM Austin, Texas 78701 (US)	(72) Inventors: NICOLSON, Garth, L. Kingwood, TX 77339 (US) NAKAJIMA, Motowo Houston, TX 77035 (US) JIN, Li Houston, TX 77030 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)