(19)

(11)

EP 0 533 834 A1

(12)

(43) Date of publication: 31.03.1993 Bulletin 1993/13 (21) Application number: 91912402.0 (22) Date of filing: 14.06.1991

(51) International Patent Classification (IPC):  A61K( . ) A61K 31/ 70( . ) A61K 35/ 12( . ) A61K 38/ 13( . ) A61K 39/ 395( . ) A61K 47/ 48( . ) C07H 15/ 04( . ) C07K 16/ 18( . ) G01N 33/ 569( . ) A61K 9/ 127( . ) A61K 31/ 715( . ) A61K 38/ 00( . ) A61K 39/ 00( . ) A61K 39/ 40( . ) C07H 3/ 06( . ) C07H 15/ 10( . ) C12N 9/ 10( . ) (86) International application number: PCT/US1991/004284 (87) International publication number: WO 1991/019502 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 15.06.1990 US 19900538853 28.11.1990 US 19900619319 21.12.1990 US 19900632390 22.05.1991 WO 1991US03592 (71) Applicant: CYTEL CORPORATION San Diego, CA 92121 (US)	(72) Inventors: PAULSON, James, C. Sherman Oaks, CA 91403 (US) PEREZ, Mary, S. Carlsbad, CA 92008 (US) GAETA, Federico, C., A. La Jolla, CA 92037 (US) RATCLIFFE, Robert, Murray Carlsbad, CA 92008 (US) (74) Representative: Armitage, Ian Michael  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)