(19)
(11) EP 0 534 988 A1

(12)

(43) Date of publication:
07.04.1993 Bulletin 1993/14

(21) Application number: 91908968.0

(22) Date of filing: 01.05.1991
(51) International Patent Classification (IPC): 
C07K 7/ 08( . )
C07K 16/ 40( . )
A61K 38/ 00( . )
C07K 16/ 36( . )
C12P 21/ 08( . )
(86) International application number:
PCT/US1991/002990
(87) International publication number:
WO 1991/017258 (14.11.1991 Gazette 1991/26)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 10.05.1990 US 19900521820

(71) Applicants:
  • CETUS CORPORATION
    Emeryville California 94608 (US)
  • NUIJENS, Jan, H.
    NL-1006 AK Amsterdam (NL)
  • HUIJBREGTS, Cecile, C.,M.
    NL-1006 AK Amsterdam (NL)
  • HACK, C.,Erik
    NL-1006 AK Amsterdam (NL)

(72) Inventors:
  • NUIJENS, Jan, H., Central Laboratory of the
    P.O. BBox 9406 NL-1006 AK Amsterdam (NL)
  • HUIJBREGTS, Cecile, C., M., Central Laboratory of
    ce P.O. Box 9406 NL-1006 AK Amsterdam m (NL)
  • HACK, C., Erik, Central Laboratory of the
    P.O. Box 9406 NL-1006 AK Amsterdam (NL)

(74) Representative: van Loon, C.J.J. 
Vereenigde Octrooibureaux Nieuwe Parklaan 97
NL-2587 BN Den Haag
NL-2587 BN Den Haag (NL)

   


(54) INHIBITORS OF FACTOR XII ACTIVATION AND APPLICATIONS THEREOF