(19)

(11)

EP 0 535 037 A1

(12)

(43) Date of publication: 07.04.1993 Bulletin 1993/14 (21) Application number: 91910869.0 (22) Date of filing: 12.06.1991

(51) International Patent Classification (IPC):  A61K 38/ 48( . ) A61P 7/ 02( . ) C12N 9/ 68( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 38/ 46( . ) C12N 9/ 64( . ) C12N 9/ 72( . ) C12N 15/ 58( . ) (86) International application number: PCT/GB1991/000945 (87) International publication number: WO 1991/019793 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 14.06.1990 GB 19900013345 (71) Applicant: BEECHAM GROUP PLC Brentford Middlesex TW8 9EP (GB)	(72) Inventor: ROBINSON, Jeffery Hugh, SmithKline Beecham Epsomy, Surrey KT18 5XQ (GB) (74) Representative: Valentine, Jill Barbara, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)