(19)

(11)

EP 0 535 083 A1

(12)

(43) Date of publication: 07.04.1993 Bulletin 1993/14 (21) Application number: 91911674.0 (22) Date of filing: 20.06.1991

(51) International Patent Classification (IPC):  C07H 15/ 04( . ) (86) International application number: PCT/GB1991/000995 (87) International publication number: WO 1991/019724 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 20.06.1990 GB 19900013699 (71) Applicant: RHONE POULENC RORER LIMITED Dagenham, Essex RM10 XS (GB)	(72) Inventors: PITCHEN, Philippe Dagenham, Essex RM10 7XS (GB) MIOSKOWSKI, Charles Dagenham, Essex RM10 7XS (GB) (74) Representative: Bentham, Stephen, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)