CHIMERIC TOXINS WITH IMPROVED INTER-DOMAIN GEOMETRY - Patent 0535088

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EP 0 535 088 A1

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(43)	Date of publication:
	07.04.1993 Bulletin 1993/14

(21)	Application number: 91911702.0

(22)	Date of filing: 12.06.1991

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International Patent Classification (IPC):

C07K 14/ 52^{( . )}
C07K 7/ 06^{( . )}
C07K 14/ 195^{( . )}
C07K 14/ 41^{( . )}
C07K 14/ 55^{( . )}
C12N 15/ 09^{( . )}
A61K 38/ 00^{( . )}

C07K 1/ 22^{( . )}
C07K 14/ 00^{( . )}
C07K 14/ 34^{( . )}
C07K 14/ 54^{( . )}
C07K 19/ 00^{( . )}
C12P 21/ 02^{( . )}

(86)	International application number:
	PCT/US1991/004187

(87)	International publication number:
	WO 1991/019745 (26.12.1991 Gazette 1991/29)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

13.06.1990 US 19900537425

(71)	Applicant: THE UNIVERSITY HOSPITAL Department of Medicine Section of Biomolecular Medicine
	Boston, MA 02118 (US)

(72)	Inventors:
	MURPHY, John, R. Wayland, MA 01778 (US) WILLIAMS, Diane, P. Franklin, MA 02038 (US)

(74)	Representative: Wright, Simon Mark, et al
	Kilburn & Strode 30 John Street London WC1N 2DD London WC1N 2DD (GB)

(54)	CHIMERIC TOXINS WITH IMPROVED INTER-DOMAIN GEOMETRY