(19)

(11)

EP 0 535 144 A1

(12)

(43) Date of publication: 07.04.1993 Bulletin 1993/14 (21) Application number: 91912599.0 (22) Date of filing: 07.06.1991

(51) International Patent Classification (IPC):  A01H 1/ 00( . ) C12N 5/ 10( . ) C12N 15/ 82( . ) A01K 67/ 027( . ) C12N 15/ 09( . ) C12N 15/ 90( . ) (86) International application number: PCT/US1991/004006 (87) International publication number: WO 1991/019796 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 12.06.1990 US 19900536397 14.06.1990 US 19900537458 17.10.1990 US 19900597694 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventors: BRADLEY, Allan Houston, TX 77096 (US) DAVIS, Ann, C. Houston, TX 77096 (US) HASTY, Paul Houston, TX 77030 (US) (74) Representative: Armitage, Ian Michael  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)