(19)

(11)

EP 0 536 119 A1

(12)

(43) Date of publication: 14.04.1993 Bulletin 1993/15 (21) Application number: 90912260.0 (22) Date of filing: 26.06.1990

(51) International Patent Classification (IPC):  A61K 31/ 195( . ) A61K 31/ 35( . ) A61K 31/ 415( . ) A61K 31/ 45( . ) A61K 31/ 60( . ) A61P 37/ 00( . ) C07D 311/ 30( . ) A61K 31/ 34( . ) A61K 31/ 352( . ) A61K 31/ 4166( . ) A61K 31/ 505( . ) A61K 45/ 00( . ) C07D 233/ 74( . ) C07D 491/ 107( . ) (86) International application number: PCT/US1990/003618 (87) International publication number: WO 1992/000071 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (71) Applicant: WASHINGTON RESEARCH FOUNDATION Seattle, WA 98105 (US)	(72) Inventors: CLARK, John, Irwin Seattle, WA 98112 (US) FARR, Andrew, Grant Seattle, WA 98105 (US) SMITH, Stacia, Ann San Diego, CA 92107 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Bakers Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)