(19)

(11)

EP 0 536 213 A1

(12)

(43) Date of publication: 14.04.1993 Bulletin 1993/15 (21) Application number: 91911788.0 (22) Date of filing: 28.06.1991

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 14/ 47( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12N 15/ 09( . ) C12N 15/ 85( . ) C12Q 1/ 68( . ) C12R 1/ 91( . ) (86) International application number: PCT/GB1991/001057 (87) International publication number: WO 1992/000375 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.06.1990 GB 19900014446 13.07.1990 GB 19900015488 09.05.1991 GB 19910010085 (71) Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED London WC2A 3NL (GB)	(72) Inventors: GOODFELLOW, Peter, Neville London WC2A 3PX (GB) LOVELL-BADGE, Robin Medical Research Council Mill Hill London NW7 1AD (GB) (74) Representative: Cresswell, Thomas Anthony, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)