(19)

(11)

EP 0 536 245 A1

(12)

(43) Date of publication: 14.04.1993 Bulletin 1993/15 (21) Application number: 91912264.0 (22) Date of filing: 21.06.1991

(51) International Patent Classification (IPC):  A61K 9/ 08( . ) C07K 14/ 575( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) A61K 38/ 28( . ) C07K 14/ 62( . ) C12P 21/ 06( . ) (86) International application number: PCT/DK1991/000167 (87) International publication number: WO 1992/000321 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.06.1990 DK 19900001556 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventors: MARKUSSEN, Jan DK-2730 Herlev (DK) LANGKJAER, Liselotte DK-2930 Klampenborg (DK) NORRIS, Kjeld DK-2900 Hellerup (DK) SNEL, Leo, Boye DK-2000 Frederiksberg (DK) (74) Representative: Noergaard, Torsten, et al  c/o Novo Nordisk A/S Novo Allé DK-2880 Bagsvaerd DK-2880 Bagsvaerd (DK)