ANTIHYPERCHOLESTEROLEMIC BIS-TRIFLUOROMETHYL-SUBSTITUTED IMIDAZOLINES AND DERIVATIVES THEREOF - Patent 0536316

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(11)

EP 0 536 316 A1

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(43)	Date of publication:
	14.04.1993 Bulletin 1993/15

(21)	Application number: 91913532.0

(22)	Date of filing: 31.05.1991

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International Patent Classification (IPC):

A61K 31/ 415^{( . )}
A61P 3/ 06^{( . )}
C07D 233/ 22^{( . )}
C07D 233/ 42^{( . )}
C07D 233/ 48^{( . )}
C07D 233/ 70^{( . )}
C07D 405/ 12^{( . )}

A61K 31/ 4166^{( . )}
A61P 9/ 10^{( . )}
C07D 233/ 32^{( . )}
C07D 233/ 44^{( . )}
C07D 233/ 54^{( . )}
C07D 233/ 88^{( . )}
C07D 409/ 12^{( . )}

(86)	International application number:
	PCT/US1991/003854

(87)	International publication number:
	WO 1991/019476 (26.12.1991 Gazette 1991/29)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

05.06.1990 US 19900533565

(71)	Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY
	Wilmington, Delaware 19898 (US)

(72)	Inventors:
	BILLHEIMER, Jeffrey, Thomas West Chester, PA 19382 (US) BOSWELL, George, Albert, Jr. Wilmington, DE 19806 (US) DE LUCCA, Indawati Wilmington, DE 19810 (US) DRUMMOND, Spencer, Jr. Wilmington, DE 19805 (US) GILLIES, Peter, John Hockessin, DE 19707 (US) TRZASKOS, James, Michael Boothwyn, PA 19061 (US)

(74)	Representative: von Kreisler, Alek, Dipl.-Chem.
	Patentanwälte von Kreisler-Selting-Werner Postfach 10 22 41 D-50462 Köln D-50462 Köln (DE)

(54)	ANTIHYPERCHOLESTEROLEMIC BIS-TRIFLUOROMETHYL-SUBSTITUTED IMIDAZOLINES AND DERIVATIVES THEREOF