(19)

(11)

EP 0 536 322 A1

(12)

(43) Date of publication: 14.04.1993 Bulletin 1993/15 (21) Application number: 91913839.0 (22) Date of filing: 24.06.1991

(51) International Patent Classification (IPC):  A61K 38/ 21( . ) A61P 29/ 00( . ) A61P 37/ 00( . ) C07K 14/ 52( . ) C12N 5/ 10( . ) C12N 15/ 19( . ) C12P 21/ 08( . ) G01N 33/ 53( . ) C12R 1/ 19( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 14/ 00( . ) C07K 16/ 24( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) A61K 38/ 00( . ) C12R 1/ 865( . ) (86) International application number: PCT/US1991/004482 (87) International publication number: WO 1992/000327 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 22.06.1990 US 19900541897 19.06.1991 US 19910715194 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)	(72) Inventors: TEKAMP-OLSON, Patricia San Anselmo, CA 94960 (US) GALLEGOS, Carol, Ann Albany, CA 94706 (US) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)