(19)

(11)

EP 0 536 360 A1

(12)

(43) Date of publication: 14.04.1993 Bulletin 1993/15 (21) Application number: 92908796.0 (22) Date of filing: 03.03.1992

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 31/ 545( . ) A61K 31/ 43( . ) A61K 47/ 10( . ) (86) International application number: PCT/US1992/001405 (87) International publication number: WO 1992/015299 (17.09.1992 Gazette 1992/24)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI NL SE (30) Priority: 05.03.1991 US 19910664795 (71) Applicants: BLOOM, Leonard Towson, Maryland 21204 (US) TOWSEND, Marvin S. Rockville, MD 20854 (US) ROBINSON, Howard N. Lutherville, MD 21093 (US) MARTIN, Neil F. Potomac, MD 20854 (US)	(72) Inventors: ROBINSON, Howard, N. Lutherville, MD 21093 (US) MARTIN, Neil, F. Potomac, MD 20854 (US) (74) Representative: Colens, Alain  c/o Bureau Colens SPRL rue Frans Merjay 21 B-1060 Bruxelles B-1060 Bruxelles (BE)