(19)

(11)

EP 0 537 163 A1

(12)

(43) Date of publication: 21.04.1993 Bulletin 1993/16 (21) Application number: 91908562.0 (22) Date of filing: 11.03.1991

(51) International Patent Classification (IPC):  A01H 1/ 00( . ) C07K 14/ 005( . ) C07K 14/ 195( . ) C12N 9/ 12( . ) C12N 15/ 82( . ) C12R 1/ 92( . ) A01H 5/ 00( . ) C07K 14/ 08( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1991/001631 (87) International publication number: WO 1991/013542 (19.09.1991 Gazette 1991/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 12.03.1990 US 19900491473 (60) Divisional application: 02024063.6 /  (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventors: ZAITLIN, Milton Ithaca, NY 14850 (US) GOLEMBOSKI, Daniel Ithaca, NY 14850 (US) LOMONOSSOFF, George Norwich NR2 4JB (GB) (74) Representative: Allam, Peter Clerk  LLOYD WISE, TREGEAR & CO. Norman House 105-109 Strand London WC2R 0AE London WC2R 0AE (GB)