(19)

(11)

EP 0 537 167 A1

(12)

(43) Date of publication: 21.04.1993 Bulletin 1993/16 (21) Application number: 91909071.0 (22) Date of filing: 16.04.1991

(51) International Patent Classification (IPC):  A61F 2/ 06( . ) A61L 27/ 16( . ) A61L 27/ 28( . ) A61L 27/ 04( . ) A61L 27/ 18( . ) A61L 27/ 38( . ) (86) International application number: PCT/US1991/002662 (87) International publication number: WO 1991/016009 (31.10.1991 Gazette 1991/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.04.1990 US 19900513284 01.02.1991 US 19910650561 (71) Applicant: CURATIVE TECHNOLOGIES, INC. Setauket, New York 11733 (US)	(72) Inventors: KNIGHTON, David, R. Minneapolis, MN 55410 (US) FIEGEL, Vance New Brighton, MN 55112 (US) CAVALLINI, Marco I-00167 Roma (IT) (74) Representative: van Loon, C.J.J., et al  Vereenigde Octrooibureaux Nieuwe Parklaan 97 NL-2587 BN Den Haag NL-2587 BN Den Haag (NL)