(19)

(11)

EP 0 537 222 A1

(12)

(43) Date of publication: 21.04.1993 Bulletin 1993/16 (21) Application number: 91911923.0 (22) Date of filing: 28.06.1991

(51) International Patent Classification (IPC):  A61K 39/ 395( . ) C07K 16/ 06( . ) G01N 33/ 574( . ) A61K 47/ 48( . ) G01N 33/ 532( . ) (86) International application number: PCT/EP1991/001223 (87) International publication number: WO 1992/000763 (23.01.1992 Gazette 1992/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 03.07.1990 EP 19900201781 (71) Applicant: AKZO N.V. NL-6824 BM Arnhem (NL)	(72) Inventors: BOS, Ebo, Sybren NL-5344 JA Oss (NL) BOON, Petrus, Johannes NL-5345 TK Oss (NL) (74) Representative: Hermans, Franciscus G.M., et al  P.O. Box 20 NL-5340 BH Oss NL-5340 BH Oss (NL)