(19)

(11)

EP 0 537 247 A1

(12)

(43) Date of publication: 21.04.1993 Bulletin 1993/16 (21) Application number: 91912526.0 (22) Date of filing: 19.06.1991

(51) International Patent Classification (IPC):  A61K 39/ 21( . ) C12N 7/ 01( . ) C12N 7/ 00( . ) C12N 15/ 00( . ) (86) International application number: PCT/US1991/004374 (87) International publication number: WO 1991/019795 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.06.1990 US 19900540529 11.12.1990 US 19900625958 (71) Applicant: IMMUVAX Los Angeles, CA 90048 (US)	(72) Inventors: PIECZENIK, George New York, NY 10023 (US) SCOLARO, Michael Los Angeles, CA 90057 (US) DURHAM, Roy Los Angeles, CA 90048 (US) (74) Representative: Fisher, Adrian John  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)