(19)
(11) EP 0 537 293 A1

(12)

(43) Date of publication:
21.04.1993 Bulletin 1993/16

(21) Application number: 91914867.0

(22) Date of filing: 01.07.1991
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
A61K 39/ 395( . )
C07K 14/ 00( . )
C07K 16/ 00( . )
C07K 19/ 00( . )
C12N 1/ 19( . )
C12N 5/ 10( . )
C12N 15/ 09( . )
C12P 21/ 08( . )
G01N 33/ 15( . )
G01N 33/ 53( . )
G01N 33/ 577( . )
A61K 39/ 00( . )
A61P 37/ 00( . )
C07K 14/ 705( . )
C07K 16/ 28( . )
C12N 1/ 15( . )
C12N 1/ 21( . )
C12N 15/ 02( . )
C12P 21/ 02( . )
C12Q 1/ 02( . )
G01N 33/ 50( . )
G01N 33/ 569( . )
C12R 1/ 91( . )
(86) International application number:
PCT/US1991/004682
(87) International publication number:
WO 1992/000092 (09.01.1992 Gazette 1992/02)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 02.07.1990 US 19900547980
27.06.1991 US 19910722101

(71) Applicant: Bristol-Myers Company
New York New York 10154 (US)

(72) Inventors:
  • LINSLEY, Peter, S.
    Seattle, WA 98119 (US)
  • LEDBETTER, Jeffrey, A.
    Seattle, WA 98177 (US)
  • DAMLE, Nitin, K.
    Renton, WA 98056 (US)
  • BRADY, William
    Bothell, WA 98021 (US)

(74) Representative: Kinzebach, Werner, Dr., et al 
Patentanwälte Reitstötter, Kinzebach und Partner Postfach 86 06 49
D-81633 München
D-81633 München (DE)

   


(54) LIGAND FOR CD28 RECEPTOR ON B CELLS AND METHODS