(19)

(11)

EP 0 538 268 A1

(12)

(43) Date of publication: 28.04.1993 Bulletin 1993/17 (21) Application number: 91910021.0 (22) Date of filing: 10.05.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 19/ 00( . ) A61K 47/ 48( . ) C07K 17/ 02( . ) (86) International application number: PCT/US1991/003291 (87) International publication number: WO 1991/017761 (28.11.1991 Gazette 1991/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 11.05.1990 US 19900522653 (71) Applicant: THE UNIVERSITY OF CONNECTICUT Storrs, CT 06269 (US)	(72) Inventors: WU, George, Y. Bloomfield, CT 06002 (US) WU, Catherine, H. Bloomfield, CT 06002 (US) (74) Representative: Holdcroft, James Gerald, Dr.  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)