(19)
(11) EP 0 538 318 A1

(12)

(43) Date of publication:
28.04.1993 Bulletin 1993/17

(21) Application number: 91912587.0

(22) Date of filing: 05.07.1991
(51) International Patent Classification (IPC): 
A61K 39/ 02( . )
A61K 39/ 10( . )
A61K 39/ 108( . )
C07K 14/ 005( . )
C07K 14/ 22( . )
C07K 14/ 41( . )
C12N 15/ 09( . )
C12P 21/ 02( . )
A61K 39/ 00( . )
C12R 1/ 91( . )
 A61K 39/ 095( . )
A61K 39/ 102( . )
A61P 31/ 04( . )
C07K 14/ 195( . )
C07K 14/ 245( . )
C07K 14/ 705( . )
C12N 15/ 75( . )
A61K 38/ 00( . )
C12R 1/ 36( . )
(86) International application number:
PCT/FI1991/000212
(87) International publication number:
WO 1992/001001 (23.01.1992 Gazette 1992/03)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 06.07.1990 FI 19900003414

(71) Applicant: THE FINNISH NATIONAL PUBLIC HEALTH INSTITUTE
SF-00300 Helsinki (FI)

(72) Inventors:
  • SARVAS, Matti
    SF-00630 Helsinki (FI)
  • BUTCHER, Sarah
    SF-02150 Espoo (FI)
  • NURMINEN-KALLIOKOSKI, Marjatta
    SF-00950 Helsinki (FI)
  • RUNEBERG-NYMAN, Kate
    SF-00250 Helsinki (FI)
  • MUTTILAINEN, Susanna
    SF-00260 Helsinki (FI)
  • WAHLSTRÖM, Eva
    SF-00260 Helsinki (FI)
  • IDÄNPÄÄN-HEIKKILÄ, Ilona
    SF-00150 Helsinki (FI)
  • PUOHINIEMI, Ritvaleena
    SF-01600 Vantaa (FI)

(74) Representative: Kolb, Helga, Dr. Dipl.-Chem., et al 
Hoffmann, Eitle & Partner, Patentanwälte, Postfach 81 04 20
D-81904 München
D-81904 München (DE)

   


(54) PRODUCTION OF OUTER MEMBRANE (OM) PROTEINS IN GRAM-POSITIVE BACTERIA AND RECOVERY OF PROTECTIVE EPITOPES