(19)

(11)

EP 0 538 459 A1

(12)

(43) Date of publication: 28.04.1993 Bulletin 1993/17 (21) Application number: 92913004.0 (22) Date of filing: 11.05.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 46( . ) C07K 14/ 315( . ) C12N 9/ 70( . ) A61K 38/ 43( . ) A61P 7/ 02( . ) C07K 14/ 47( . ) C12N 9/ 72( . ) (86) International application number: PCT/US1992/003960 (87) International publication number: WO 1992/019279 (12.11.1992 Gazette 1992/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 09.05.1991 US 19910697364 (71) Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON Seattle, Washington 98195 (US)	(72) Inventors: TAIT, Jonathan Seattle, WA 98125 (US) FUJIKAWA, Kazuo Seattle, WA 98105 (US) (74) Representative: Kraus, Walter, Dr., et al  Patentanwälte Kraus, Weisert & Partner Thomas-Wimmer-Ring 15 D-80539 München D-80539 München (DE)