(19)

(11)

EP 0 539 372 A1

(12)

(43) Date of publication: 05.05.1993 Bulletin 1993/18 (21) Application number: 91903536.0 (22) Date of filing: 26.01.1991

(51) International Patent Classification (IPC):  A61K 31/ 415( . ) C07D 311/ 22( . ) C07D 401/ 04( . ) C07D 491/ 052( . ) A61P 37/ 00( . ) C07D 335/ 06( . ) C07D 491/ 04( . ) C07D 495/ 04( . ) (86) International application number: PCT/EP1991/000154 (87) International publication number: WO 1991/011448 (08.08.1991 Gazette 1991/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 02.02.1990 GB 19900002314 02.02.1990 GB 19900002315 06.02.1990 GB 19900002425 (71) Applicant: The Boots Company PLC Nottingham Nottinghamshire NG2 3AA (GB)	(72) Inventors: TITMAN, Roger Bernard, The Boots Company plc Nottingham NG2 3AA (GB) HOCKLEY, Michael Henry, The Boots Company plc Nottingham NG2 3AA (GB) GILL, Onkar Singh Surrey CR7 6DE (GB) (74) Representative: Smith, Elizabeth Jane  The Boots Company PLC Group Patents Department 10th Floor, Newland House 49 Mount Street Nottingham NG2 3AA Nottingham NG2 3AA (GB)