(19)

(11)

EP 0 539 418 A1

(12)

(43) Date of publication: 05.05.1993 Bulletin 1993/18 (21) Application number: 91912594.0 (22) Date of filing: 04.07.1991

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) C07D 471/ 04( . ) A61P 37/ 08( . ) (86) International application number: PCT/EP1991/001256 (87) International publication number: WO 1992/000978 (23.01.1992 Gazette 1992/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 13.07.1990 GB 19900015524 (71) Applicants: Pfizer Limited Sandwich Kent CT13 9NJ (GB) PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventors: COOPER, Kelvin Sandwich, Kent CT13 9NJ (GB) FRAY, Michael Jonathan Sandwich, Kent CT13 9NJ (GB) STEELE, John Sandwich, Kent CT13 9NJ (GB) (74) Representative: Moore, James William, Dr., et al  Pfizer Limited Ramsgate Road Sandwich Kent CT13 9NJ Sandwich Kent CT13 9NJ (GB)