(19)

(11)

EP 0 539 506 A1

(12)

(43) Date of publication: 05.05.1993 Bulletin 1993/18 (21) Application number: 91914013.0 (22) Date of filing: 11.07.1991

(51) International Patent Classification (IPC):  A61K 31/ 575( . ) A61K 35/ 14( . ) A61K 38/ 44( . ) A61P 31/ 18( . ) A61K 33/ 00( . ) A61K 38/ 00( . ) A61P 31/ 12( . ) C07K 14/ 775( . ) (86) International application number: PCT/US1991/004913 (87) International publication number: WO 1992/001467 (06.02.1992 Gazette 1992/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 18.07.1990 US 19900554807 (71) Applicant: THE BETH ISRAEL HOSPITAL ASSOCIATION Boston, MA 02215 (US)	(72) Inventors: FOSSEL, Eric, T. Chestnut Hill, MA 02167 (US) LYDDY, James, E. Arlington, MA 02174 (US) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)