(19)

(11)

EP 0 539 591 A1

(12)

(43) Date of publication: 05.05.1993 Bulletin 1993/18 (21) Application number: 91913066.0 (22) Date of filing: 17.07.1991

(51) International Patent Classification (IPC):  A61K 31/ 55( . ) A61P 1/ 00( . ) C07D 243/ 16( . ) C07D 243/ 20( . ) C07D 401/ 14( . ) C07D 403/ 14( . ) A61K 31/ 551( . ) A61P 43/ 00( . ) C07D 243/ 18( . ) C07D 243/ 24( . ) C07D 403/ 06( . ) (86) International application number: PCT/JP1991/000952 (87) International publication number: WO 1992/001683 (06.02.1992 Gazette 1992/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.07.1990 GB 19900015879 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP)	(72) Inventors: SATO, Yoshinari Takaishi-shi, Osaka 592 (JP) ITANI, Hiromichi Akashi-shi, Hyogo 673 (JP) OGAHARA, Takatomo Hiroshima-shi, Hiroshima 731-51 (JP) (74) Representative: Türk, Dietmar, Dr. rer. nat.  Türk, Gille, Hrabal, Leifert Patentanwälte Brucknerstrasse 20 D-40593 Düsseldorf D-40593 Düsseldorf (DE)