(19)

(11)

EP 0 540 575 A1

(12)

(43) Date of publication: 12.05.1993 Bulletin 1993/19 (21) Application number: 91913186.0 (22) Date of filing: 02.07.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 1/ 16( . ) C07K 1/ 20( . ) C07K 14/ 435( . ) C07K 14/ 53( . ) A61P 7/ 00( . ) C07K 1/ 18( . ) C07K 1/ 26( . ) C07K 14/ 52( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1991/004698 (87) International publication number: WO 1992/000319 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 02.07.1990 US 19900547573 (71) Applicant: HIPPLE CANCER RESEARCH CENTER Dayton, OH 45439-2092 (US)

(72) Inventors: MURPHY, Martin, J. Centerville, OH 45459 (US) PARCHMENT, Ralph, E. Dayton, OH 45419 (US) ERICKSON-MILLER, Connie, L. Centerville, OH 45458 (US) DAI, Wei West Chester, OH 45096 (US) ZHANG, Zhao-Geng 100850 Beijing (CN) LIOTTA, Lance, A. Potomac, MD 20854 (US) KRUTZSCH, Henry Bethesda, MD 20817 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)