(19)

(11)

EP 0 540 586 A1

(12)

(43) Date of publication: 12.05.1993 Bulletin 1993/19 (21) Application number: 91913263.0 (22) Date of filing: 25.07.1991

(51) International Patent Classification (IPC):  A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 14/ 715( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) C07K 7/ 08( . ) C07K 14/ 705( . ) C07K 16/ 00( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) (86) International application number: PCT/GB1991/001253 (87) International publication number: WO 1992/001787 (06.02.1992 Gazette 1992/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 25.07.1990 GB 19900016299 (71) Applicant: CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED Melbourn, Cambridgeshire SG8 6EJ (GB)	(72) Inventors: JOHNSON, Kevin, Stuart Godmanchester, Cambridgeshire PE18 8EX (GB) JACKSON, Ronald, Henry Cambridge CB1 2NU (GB) CHISWELL, David, John Middle Claydon, Buckingham MK18 2LD (GB) (74) Representative: Harrison, David Christopher, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)