(19)

(11)

EP 0 541 654 A1

(12)

(43) Date of publication: 19.05.1993 Bulletin 1993/20 (21) Application number: 91914148.0 (22) Date of filing: 30.07.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 1/ 06( . ) C07K 7/ 08( . ) A61K 38/ 04( . ) A61P 43/ 00( . ) C07K 7/ 06( . ) (86) International application number: PCT/GB1991/001289 (87) International publication number: WO 1992/002545 (20.02.1992 Gazette 1992/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 31.07.1990 GB 19900016810 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventors: KULL, Frederick, Charles Durham, NC 27707 (US) LEBAN, Johann, Jakob Durham, NC 27707 (US) (74) Representative: Rollins, Anthony John  Group Patents & Agreements The Wellcome Foundation Ltd Langley Court Beckenham Kent BR3 3BS Beckenham Kent BR3 3BS (GB)