(19)

(11)

EP 0 541 691 A1

(12)

(43) Date of publication: 19.05.1993 Bulletin 1993/20 (21) Application number: 91914930.0 (22) Date of filing: 01.08.1991

(51) International Patent Classification (IPC):  A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 14/ 47( . ) C07K 16/ 04( . ) C07K 16/ 30( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 574( . ) C12R 1/ 91( . ) C07K 1/ 00( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) C07K 16/ 18( . ) C12N 15/ 02( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/005452 (87) International publication number: WO 1992/002554 (20.02.1992 Gazette 1992/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL (30) Priority: 01.08.1990 US 19900561989 (60) Divisional application: 04076687.5 / 1484340 (71) Applicant: THE JOHNS HOPKINS UNIVERSITY Baltimore, MD 21205 (US)	(72) Inventor: PASTERNACK, Gary, R. Baltimore, MD 21210 (US) (74) Representative: Dost, Wolfgang, Dr.rer.nat., Dipl.-Chem., et al  Patent- und Rechtsanwälte Bardehle . Pagenberg . Dost . Altenburg . Frohwitter . Geissler & Partner Postfach 86 06 20 D-81633 München D-81633 München (DE)