(19)

(11)

EP 0 542 920 A1

(12)

(43) Date of publication: 26.05.1993 Bulletin 1993/21 (21) Application number: 91917229.0 (22) Date of filing: 08.08.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 49/ 00( . ) C07K 14/ 705( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) A61P 25/ 00( . ) C12N 5/ 10( . ) C12P 21/ 00( . ) G01N 33/ 53( . ) (86) International application number: PCT/US1991/005656 (87) International publication number: WO 1992/002640 (20.02.1992 Gazette 1992/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 08.08.1990 US 19900564075 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventors: MATSUDA, Lisa, A. Gaithersburg, MD 20877 (US) BROWNSTEIN, Michael, J. Rockville, MD 20852 (US) BONNER, Tom, I. Chevy Chase, MD 20815 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)