(19)

(11)

EP 0 543 891 A1

(12)

(43) Date of publication: 02.06.1993 Bulletin 1993/22 (21) Application number: 91914898.0 (22) Date of filing: 14.08.1991

(51) International Patent Classification (IPC):  A61K 31/ 17( . ) A61P 3/ 06( . ) A61P 43/ 00( . ) C07C 275/ 42( . ) C07C 323/ 42( . ) C07C 323/ 63( . ) A61K 31/ 245( . ) A61P 9/ 10( . ) C07C 273/ 06( . ) C07C 317/ 42( . ) C07C 323/ 44( . ) (86) International application number: PCT/GB1991/001383 (87) International publication number: WO 1992/003413 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 15.08.1990 GB 19900017892 (71) Applicant: RHONE POULENC RORER LIMITED Dagenham, Essex RM10 XS (GB)	(72) Inventor: LYTHGOE, David John Dagenham, Essex RM10 7XS (GB) (74) Representative: Bentham, Stephen  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)