(19)
(11) EP 0 543 922 A1

(12)

(43) Date of publication:
02.06.1993 Bulletin 1993/22

(21) Application number: 91915805.0

(22) Date of filing: 13.08.1991
(51) International Patent Classification (IPC): 
A61K 31/ 13( . )
A61K 31/ 16( . )
A61K 31/ 18( . )
A61K 31/ 22( . )
A61P 43/ 00( . )
C12R 1/ 91( . )
 A61K 31/ 145( . )
A61K 31/ 164( . )
A61K 31/ 195( . )
A61P 35/ 00( . )
C12N 5/ 06( . )
(86) International application number:
PCT/US1991/005743
(87) International publication number:
WO 1992/003129 (05.03.1992 Gazette 1992/06)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 13.08.1990 US 19900566978

(71) Applicant: DUKE UNIVERSITY
Durham, NC 27708-0083 (US)

(72) Inventors:
  • HANNUN, Yusuf, A.
    Chapel Hill, NC 27514 (US)
  • BELL, Robert, M.
    Durham, NC 27705 (US)

(74) Representative: Colgan, Stephen James 
CARPMAELS & RANSFORD 43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) METHODS FOR INDUCING CELL DIFFERENTIATION USING CERAMIDES