(19)

(11)

EP 0 543 928 A1

(12)

(43) Date of publication: 02.06.1993 Bulletin 1993/22 (21) Application number: 91916359.0 (22) Date of filing: 19.08.1991

(51) International Patent Classification (IPC):  A61B 5/ 055( . ) G01R 33/ 563( . ) G01R 33/ 48( . ) G01R 33/ 567( . ) (86) International application number: PCT/US1991/005869 (87) International publication number: WO 1992/003089 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.08.1990 US 19900570207 15.04.1991 US 19910685915 (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia, Pennsylvania 19104-3147 (US)	(72) Inventors: AXEL, Leon Philadelphia, PA 19103 (US) SHINNAR, Meir Bala Cynwyd, PA 19004 (US) (74) Representative: Ebbinghaus, Dieter, Dipl.-Ing., et al  Patentanwälte v. Füner, Ebbinghaus, Finck Postfach 95 01 60 D-81517 München D-81517 München (DE)