(19)

(11)

EP 0 543 936 A1

(12)

(43) Date of publication: 02.06.1993 Bulletin 1993/22 (21) Application number: 91916458.0 (22) Date of filing: 02.08.1991

(51) International Patent Classification (IPC):  A61K 31/ 445( . ) A61K 31/ 495( . ) A61K 31/ 535( . ) A61P 9/ 12( . ) C07D 211/ 46( . ) C07D 405/ 12( . ) C07D 417/ 12( . ) C07D 451/ 14( . ) A61K 31/ 4427( . ) A61K 31/ 505( . ) A61K 31/ 54( . ) A61P 43/ 00( . ) C07D 401/ 12( . ) C07D 413/ 12( . ) C07D 451/ 06( . ) (86) International application number: PCT/US1991/005524 (87) International publication number: WO 1992/003429 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 15.08.1990 US 19900568557 09.04.1991 US 19910680811 (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)

(72) Inventors: BAKER, William, R. Libertyville, IL 60048 (US) BOYD, Steven, A. Mundelein, IL 60060 (US) FUNG, Anthony, K., L. Gurnee, IL 60031 (US) STEIN, Herman, H. Highland, Park, IL 60035 (US) DENISSEN, Jon, F. McHenry, IL 60050 (US) HUTCHINS, Charles, W. Gurnee, IL 60031 (US) ROSENBERG, Saul, H. Libertyville, IL 60048 (US) (74) Representative: Modiano, Guido, Dr.-Ing.  Modiano & Associati S.r.l. Via Meravigli, 16 I-20123 Milano I-20123 Milano (IT)